Machine study · 10 prompts
SERCA calcium pump
The 10 review prompts from the notes on SERCA calcium pump. Answer each in your head, then reveal it. Your grade decides when the card comes back.
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A muscle contracts when calcium floods out of a store inside each fibre. What job does SERCA do after each contraction?
SERCA pays for its work with ATP: each ATP it spends pushes blank calcium ions into the store.
In heart failure, the heart's calcium cycling falls, and SERCA activity falls with it. What treatment idea tries to fix this, and how well has it worked?
SERCA works like an airlock: one door opens to the fibre, it shuts, then a door opens to the store. Why must the two doors never be open at the same time?
SERCA does not simply burn ATP like fuel in an engine. What does it do with the phosphate group of the ATP?
After SERCA lets its two calcium ions go inside the store, its binding sites are empty. What fills the empty seats for the trip back?
SERCA pushes calcium uphill, into a store that already holds a lot. Roughly how much more free calcium is inside the store than in the resting muscle fibre?
Even at rest, a muscle keeps its pumps busy to hold calcium in the store. About how much of resting muscle's oxygen use goes to SERCA?
Calcium switches on myosin, the motor that makes muscle contract. How does SERCA switch myosin off at the end of a contraction?
A plant toxin, thapsigargin, jams SERCA. Why did it become a standard lab tool for studying calcium?
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