Machine study · 10 prompts
Myosin
The 10 review prompts from the notes on Myosin. Answer each in your head, then reveal it. Your grade decides when the card comes back.
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Myosin is the motor in your muscles, and in other cells it also hauls cargo. Along which kind of filament does it pull?
Muscle myosin heads let go of actin for most of their cycle, and each head works on its own clock. How does muscle still pull steadily?
Cardiac myosin drives every heartbeat, and it is now a drug target. What do the new cardiac myosin drugs do to this motor?
How it works 3
Read this section: How it works, in the Myosin notesA myosin head binds actin and then lets its phosphate go. What does the head do next that pulls the filament along?
After the power stroke, the myosin head stays stuck tight to actin with an empty fuel pocket. What must bind to make the head let go?
Once free of actin, the myosin head closes around its ATP and splits it. What does this do to the lever?
Big picture 3
Read this section: Big picture, in the Myosin notesEach myosin stroke moves only a few nanometres, yet a muscle shortens by centimetres. How does the layout of muscle add these strokes up?
A myosin stroke starts with a movement of about half a nanometre near one phosphate in the head. By the time it reaches your hand, roughly how many times larger has that movement grown?
A calcium signal switches muscle myosin on. Which machine switches it off again, and how?
Inside the head only a small part turns, and a long lever arm turns that into a big stroke. When engineers made the lever longer, what happened to the speed of the motor?
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